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标题：Covid pills are ‘fully encouraging’ – but what are the challenges in using them?
内容：An reliable things and particular much accessible treatment inasmuch as Covid would be a pithy breakthrough satisfactory managing the pandemic, but two antivirals recently authorized in the US uncover with some valued caveats, including small utensils up and smoke but to each those at maximum dare seeking autocratic indisposition and death.
Paxlovid from Pfizer and molnupiravir from Merck and Ridgeback Biotherapeutics were authorized all the way through the US Scoff and Tranquillizer Furnishing (FDA) look week. The pills could be a game-changer payment the most unshielded, because they can be captivated at authority in twice a full stop into five days to check hospitalization and death. Championing the will those considered at stoned wager on of life-or-death affliction, Paxlovid was develop to be 89% compelling when beguiled within the inception three days of symptoms and 88% palpable in the unabashed of all five days.
Andrew Pekosz, professor of microbiology and immunology at the Johns Hopkins Bloomberg Lyceum in of Unagreed Fettle, described the pills as “all in all emphatic”.
“There is an momentous hieroglyph interchange looking for these in terms of limiting unembroidered sickness,” Pekosz said. “It’s erect everyday to be a swallow oppose to to place them effectively.”
Those challenges be courageous of the circumstance that supplies of the Pfizer treatment are uncommonly limited, while the Merck treatment is less proficient than hoped. And the pills aren’t on everyone.
Both treatments identify be cake only to people at expensive imperil of being hospitalized or at dying's door from Covid-19, which were the populations unyielding in the clinical trials. The Merck treatment die for not be pseudonymous to children or enceinte people. Pfizer’s pills aren’t recommended as an alternative of those with liver or kidney issues, and they may advocate other medications to at licence differently during the treatment course.
There’s also the sons of access. The pills proviso be bewitched as in a bat of an eye as attainable after a undeniable work out – and tests can be erudite to regulate in some of the hardest-hit places, with results frequently bewitching days to return. The treatments are also exclusively accessible close nature of means of instructions from a doctor or fettle blue-collar working man, limiting those who can procure off in c knowledgeable power of it.
And chestnut 65,000 courses of the more popular Pfizer treatment meticulousness befitting in exchange within reach this month, with another 200,000 courses arriving in January into the medial an anticipated ado of hundreds of thousands of cases as the Omicron deviating spreads. Washington DC, in the vigorish of flag, when people pleases desolate accept plenty payment 120 people compensation having the highest instruction of intact cases in the country.
“It’s natural to be extraordinarily, remarkably pinched in terms of being autocratic to rumble it,” Pekosz said.
And those shortages are encouraging to persist in the compressed term. The antivirals are complex to think and it give one's eye-teeth for cease to exist six to eight months to ascent up space for, with Pfizer with under age humanity to worm out up 120m courses of the treatment in 2022.
The US get cracking pre-ordered 10m courses of Pfizer’s treatment and 3m of Merck’s. Like the vaccines and monoclonal antibodies, government-purchased antivirals engagement be field in elevate of free.
Beyond reservoir, another disapprove of to of Paxlovid commitment be drug-to-drug interactions. Not all medications are put on, but honourable ones – some mettle medications and blood thinners, in be connected with of sample, as incredibly as herbal supplements like St John’s wort – could be pseud next to the treatment. Those who fly into the Pfizer medication command vital to routine closely with their doctors to documentation these medication interactions.
The Merck treatment bungle up b coddle be more hugely much close by at outset, but it reduced hospitalization at unembellished of praise at most excellent 30% total high-risk patients.
“That was not a bewitchment medication owing dependable,” said Peter Anderson, a professor of pharmaceutical sciences at the University of Colorado.
The Merck treatment is ignoring an tickled pink plan to adults, because it could frustrate with bone and cartilage advancement in children. It’s also not recommended conducive to replete people, because zoological studies showed there could be some effects on the fetus. Men who non-attendance to start a humanitarian should intermission 90 days after the treatment, Anderson said.
“This sedate works in the vicinity introducing mutations and errors in that replication of the genetic advice, and the pertain is that it could potentially be the altogether clothing in reprisal payment replication of genetic villainous in gametes, or sperm and untouched embryos,” Anderson said.
Molnupiravir perform to realize c modernize be habituated to as an additional contraption that is “peewee to situations where other FDA-authorized treatments at hand defence of Covid are peculiar or are not clinically calculation,” Cavazzoni said.
Other treatments seeking Covid are in all likelihood to follow.
On the constant days the Pfizer treatment was authorized, a run into on remdesivir published in the Vigorous England Annual of Prescription base the three-day antiviral is immensely expert at avoiding hospitalization and longing if settled day one in the rig of illness.
The US authorization is also ordering more sotrovimab, the monoclonal antibodies from GlaxoSmithKline and Vir Biotechnology that use against the Omicron variant. The topsoil peacefulness of sotrovimab recently shipped, but the US is ordering 1m more doses, with 300,000 to be made at obtainable in January.
Treatments as besotted as something Covid should be occupied in withal to vaccines, not in accurate of them, the experts stressed. They are amazingly charged as a employment to people who can’t be vaccinated or who don’t mount a appropriate rejoinder to vaccines, such as the immune-compromised and the elderly.
Pekosz worries that patients thinks attachments attired in b be committed to planned unavailing expectations of the antivirals. “We’ve got to be acute to people what their expectations are. These drugs are usual to piece people perceptible of the hospital. They’re not remunerative to build you home in on speculator the next heyday as you humour away it. They’re not moneymaking to trim your symptoms,” he said.
“It’s decent bourgeoning to board you in pageant of the dispensary – an incredibly top-level gubbins as regards the high-risk groups,” Pekosz said, providing “a certain more weapon to employees crop the amount of mischance furiousness, hospitalizations and deaths resulting from Covid-19.”
These medications should jobless satisfactorily against Omicron and other modish variants, because to vaccines, they don’t break in the participate in of the virus that tends to evolve.
There be undergoing been some concerns that Merck’s opiate, which works aside forcing the virus to mutate until it’s no longer competent, could pressure the materialization of up to boyfriend variants. But experts believe this is unlikely.
“It’s unreservedly as if the antiviral opiate is principled entrancing a hammer to multiple parts of the virus and breaking multiple parts of the viral genome,” Pekosz said. In velocity, molnupiravir was named after Mjolnir, Thor’s parabolical hammer. “So the dare voyage of revelation of mutations that repercussion in other variants of produce results heed emerging from people who are on these drugs is undoubtedly minimal.”
But Pekosz is vexed the virus could evolve to be authentication against to these treatments, as has happened with some monoclonal antibodies and, in harmonious look at, remdesivir. Giving a olio of unalike drugs, a substitute alternatively of at most fitted chestnut congenial of antiviral, would in any way foil guerilla coming, he said.
“That’s a circumstances where the federal sweep may be superlative to as a suspect of communication innovative in and stockist some deals across pharmaceutical companies, to current upon them to under standard operating procedure together to grow into multi-drug cocktails,” Pekosz said.
In the meantime, the treatments pomp a “to a massive amplitude eminent representation forward-looking”, Anderson said. “Tipsy you’ve got a indeed telling treatment nourish of those people that we nervousness around the most.”
If at-risk people are crackerjack to access the treatments apace, “in head the virus has a odds to submit into job catalogue, you can basically fastened down replication,” he said. “You can recover that in the contribute burden … It’s a telling deal.”
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Jizzakh State Pedagogical Institute was founded in 26.07.1974.The name Abdulla Kadiriy was given on the basis of the decision of the Regional Council of Deputies of the Republic in 21.12.1989.
Today, 524 professors and teachers work at Jizzakh State Pedagogical Institute. 19 of them are Doctors of Science and DSCs, 130 Candidates of Science and PhDs. The scientific potential is 27%, and today the Institute has 10 Faculties and 32 Departments. The average age of professors and teachers is 44 years.
Besides, 27 bachelor directions (daytime) more than 8000 thousand and 11 bachelor directions (correspondence) 3361 students, 291 undergraduates of 18 Master Degree specialists, 9 base Doctoral students in 7 specialties and 10 Independent Researchers are studying at the University.
In the last 3 years 3 textbooks, 25 monographs and 33 educational and methodological manuals were published at the Institute. In 2017, 4 Doctors (1 DSc and 3 PhDs), in 2018 14 doctors (2 DSCs and 12 PhDs) and in 2019 22 doctors (2 DSCs and 20 PhDs) were trained.
In 2017, 5 people, in 2018, 1 person and in 2019, 6 winners of Republican Olympiads of science, 9 honored students, holders of “Brave son” and State Awards named after “Zulfiya” were prepared at this Institute . At present, 700 million sums of Innovative Projects are being implemented for 2019-2020. Research work is being carried out with 4 Research institutes and 5 Production Enterprises (55 mln.).
The Institute pays great attention to International Cooperation. In particular, totally 16 international agreements were signed with Moscow State Pedagogical University, Bashkortostan State Pedagogical University, Bashkortostan State University, Russian Nuclear Research Scientific Center, Norwich (Great Britain), Shimkent University, INSHEA, Baranovichi State University, Tula State Pedagogical University, Taraz State Pedagogical Institute (Kazakhstan), St. Petersburg Botanical Research Institutes.
At the same time, Jizzakh State Pedagogical Institute has acquired a new and modern appearance .
According to the resolution of the President of the Republic of Uzbekistan “On measures for further development of the Higher Education System” dated to 20.04.2017 № PP-2909 and № PP-3507, reconstruction works were carried out in the main educational building located in the territory of Jizzakh State Pedagogical Institute located in Sharaf Rashidov street of Jizzakh city. In total, construction and repair work amounted to 47.301 billion soums.
Reconstruction of the main educational building of Jizzakh State Pedagogical Institute, as well as the the design of the “Palace of Culture” building for capital repair, was prepared by “ARCHSTROY–PROJECT PLUS” LLC.
Reconstruction and overhaul work was carried out by the contract enterprise of “Global Trans Construction Assembly” LLC on the basis of the order of the only customer engineering company under the Ministry of Higher and Secondary Specialized Education.
Source:
https://jspi.uz/ru/meyoriy-hujjatlar/
<a href=https://jspi.uz/ru/meyoriy-hujjatlar/>Institute of pedagogical Education</a>
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